Abstract: Our works aims to deal with the shortage that the GSM security mechanism only supports air interface encryption, and to provide end-to-end secure communication. Based on the DSP hardware, a novel encryption algorithm is designed, which can penetrate through RPE-LTP vocoder in GSM voice channel. Meanwhile, an audio codec circuit board is made to realize full-duplex communication. In addition, the external hanging design makes our works plug-and-play to the mobile phone’s headset jack. The functions of our works also feature as follows. Our works can overcomes the shortages of the technologies based on the data channel. Besides, the time delay is short, the encryption intensity is strong enough, and the decrypted voice has high intelligibility. No modification of mobile phone and the networks is needed. Our works also has good compatibility to different mobile networks.